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ASAP Structural and Metal Ion Effects on Human Topoisomerase IIa

ASAP Structural and Metal Ion Effects on Human Topoisomerase IIa

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ASAP Structural and Metal Ion Effects on Human Topoisomerase IIa Inhibition by a-(N)-Heterocyclic Thiosemicarbazones | Toxic | Pinterest | Metal

Proposed two-metal-ion mechanism for DNA cleavage and ligation mediated by type II topoisomerases. A novel variant of the canonical two-metal-ion mechanism ...

A two-metal-ion model for DNA cleavage by human topoisomerase IIα. Details

(a) Domain arrangement of type IIA topoisomerases. Functional regions are colored and labeled. CTR, C-terminal region. (b) Model of the ternary complex.

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T-segment DNA capture and transport by type IIA topoisomerases. a The proposed type II topoisomerase reaction cycle exemplified by topoisomerase IV.

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Mechanism of DNA cleavage and ligation mediated by topoisomerase II. The type II enzyme utilizes

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(a) Poisoned topo II results in a tyrosine covalently linked to the 5′-phosphate of a DSB with 5′ overhangs. The 5′-Y bond is cleaved by Tdp2. (b) Domain ...

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ASAP Chemicals and Drugs Forming Reactive Quinone and Quinone Imine Metabolites | Toxic | Pinterest | Drugs

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Schematic drawing of DNA gyrase primary structure in comparison with that of eukaryotic topoisomerase II.

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a, S. cerevisiae topo II domain arrangement. Functional regions are coloured and labelled. Active-site residues are red; 'trapdoor' residues green. b, ...

(a) The GHL ATPase domains (yellow and orange) of type IIB (left) and type IIA (right) topoisomerases are highly structurally related, whereas the ...

NO2 Suppression of Autoxidation–Inhibition of Gas-Phase Highly Oxidized Dimer Product Formation #NO2 | Toxic | Pinterest

ASAP Novel Anaerobic Electrochemical Membrane Bioreactor with a CNTs Hollow Fiber Membrane Cathode to Mitigate Membrane Fouling and Enhance…

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Comparison of metal occupancy between type IIA topoisomerase structures. (a) The structure of

ASAP Information-Derived Mechanistic Hypotheses for Structural Cardiotoxicity | Toxic

ASAP less than italic toggle="yes" greater than Aedes aegypti less than /italic greater than Galectin Competes with Cry11Aa for Binding to…

Chemical structures of (a) QPT-1, (b) etoposide and (c) moxifloxacin (with associated magnesium ion). (d) Schematic of structure of S. aureus gyrase CORE ...

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Transcription incurs topological constraints that result from the progression of RNA polymerase II (Pol II). Positive supercoiling (Sc+) of the DNA template ...

a, Domain arrangement of S. cerevisiae Topo II: metal-binding TOPRIM ( TOpoisomerase/PRIMase) fold, cyan; linker domain, yellow; WHD, magenta; tower domain, ...

a, Stereo view showing the E. coli DNA topoisomerase III active site in the presence and absence of DNA. Residues from the apo structure are shown in blue, ...

Moving the position of the linked etoposide core along the bottom strand (OTI) sequence

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Crystal structure of the S. cerevisiae topoisomerase II bound to DNA (PDB: 4GFH

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DNA topoisomerases in bacteria and plants: mechanism and drug-targeting

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ASAP Intact Cell Lipidomics Reveal Changes to the Ratio of Cardiolipins to Phosphatidylinositols in Response to Kanamycin in HeLa and…

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ASAP Climate Change Mitigation, Air Pollution, and Environmental Justice in… #Air_Pollution #Climate_Change #Environmental_Justice | Toxic | Pinterest | Air ...

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(A) The top 10 GO biological processes. (B) The top 10 GO cellular components. (C) The top 10 GO molecular functions. GO, Gene Ontology; TOP, topoisomerase.

X-ray crystal structures of the functional unit of a complex of CtGEN1 bound to

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Overall structure of the E. coli DNA topoisomerase III–ssDNA complex.a,

Cleavage patterns by human topoisomerase II at the replication origin region of

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Representative newer quinolone-class antibacterial agents found to be equipotent or near equipotent inhibitors of

DNA topoisomerase IIA dimer, Human

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Structures of the ...

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ASAP Biodegradable Plastic Blends Create New Possibilities for End-of-Life Management of Plastics but They Are Not a… #Biodegradable | Toxic | Pinterest ...

(A) Representation of the GyrA-GyrB truncated core fusion (PDB 4PLB)

Structural organization of the Toprim domain in the topoisomerase family. (A) Schematic representation. Effects of magnesium and related divalent metal ions ...

Figure 8.

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Crystal structures of the individual domains of type II topoisomerases, as defined in Fig.

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Effects of Common Buffer Systems on Drug Activity: The Case of Clerocidin

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Susceptibility of Standard E. coli Strains against Bisbenzimidazole Analogs and their Topoisomerase I Inhibitory

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(A) Comparison of human topoisomerase IIa and IIb. Amino acid

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The Mn2+ ion is the purple sphere. b, The active site in the 3 Å yeast Topo II complex (PDB accession 2RGR).

The structure of human GSTP1-1 in complex with GSH and the inhibitor NBDHEX is shown (pdb code 3GUS). The N-terminal thioredoxin-like domain is coloured in ...

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Structures of the purine bases guanine (G) and adenine (A) and the

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LDA analysis of the divalent metal binding site. (a) Histogram of projection values of 685 bound Mg(II) molecules (top) and 685 bound Mn(II) molecules ...

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Chemical structures of copper(II) complexes (L' and L

Generation and scavenging of reactive oxygen species (ROS).

(a) Left, structure of full-length EcTopoI with the C-terminal zinc-finger domains (V–IX) bound to ssDNA. Right, the structure of the EcTopoI 67-kD ...

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Fluoroquinolone/dione-gyrase/topoisomerase IV-DNA complex. The structure of moxifloxacin

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The general structure of copper(II) and platinum(II) metal complexes where